[Mother Abigail]

Preiser's caution on the interpretation of these results is paramount here: "It needs to be emphasised that at this point of time these preliminary results only indicate a suspicion. Furthermore, even if the presence of a paramyxovirus was confirmed, it is not clear at this stage whether this might represent the causal agent of SARS or rather a coincidental finding."

Confirmation of these findings will be important as well as identification of a similar agent from additional cases of SARS will be necessary before it can be concluded that this agent is the etiology of SARS. - Mod.MPP]

[Paramyxoviruses are viruses associated predominantly with respiratory infections (the parainfluenza viruses, and respiratory syncytial virus (RSV)) and common childhood illnesses (mumps and measles).

Some of these viruses are ubiquitous (in particular human RSV) and it would not be exceptional to detect one of these viruses fortuitously by electron microscopy in any virus screening exercise. In general, paramyxoviruses only infect vertebrates and no arthropod vectors are known.


Unexpectedly, in recent years several new paramyxoviruses have been discovered. Predominant among these are _Hendra virus_ and _Nipah virus_, 2 related viruses isolated from bats in Australia and South East Asia, which have been responsible for outbreaks of severe disease in the human population. These two viruses differ significantly from other paramyxoviruses in molecular terms and might not be detected by PCR without the use of specific primers.

Other novel paramyxoviruses of unknown pathogenic potential are _Salem virus_, isolated from a horse in North America, _Tupaia paramyxovirus_, isolated from a tree shrew (_Tupaia_ sp.) in Thailand, and a heterogeneous collection of paramyxoviruses isolated from snakes, lizards, and turtles. Perhaps the most surprising discovery was the recent characterization of a novel pneumovirus (that is, a member of the sub-family _Pneumovirinae_ of the family _Paramyxoviridae)), designated _Human metapneumovirus_, which is associated with respiratory illness in infancy worldwide. Consequently a novel paramyxovirus must rank high among candidates for the etiologic agent of SARS. - Mod.CP]

[Robert DeLong]

Yeah that really cleared it up!!!!

[Endeavor]

Mother Abigail does a nice explanation here in post #13.

The gist of it is, just because they found particles that may be paramyxovirus doesn't mean that's the causitive organism. Paramyxoviruses cause a variety of diseases from mumps to parainfluenza.

This is simply a preliminary report - not even sure that they even have identified enough viral particle to determine if it's a paramyxovirus for sure yet. If it is a paramyxo particle, it could be incidental or it could be the causitive agent. More tests need to be done.

[Monster Zero]

Interesting choice of screen names you got there.

[HardStarboard]

>>> In general, paramyxoviruses only infect vertebrates and no arthropod vectors are known. <<<

Well, that clears it up.

{/sarcasm}

[bonesmccoy]

Great information!

I especially appreciated the information on viral serologies. Based in part on the reports associated with these threads, we have initiated more advanced diagnostics associated with febrile illnesses in infants and children.

RSV appears to be running through our region still.

paramyxovirus is an interesting issue.

If you have a pointer to CDC or NIH web pages on the family of viruses, please post.

I have been reviewing the ProMed stuff after you posted the links.

Thanks.

You've done more of our practice than local public health has.