[_Jim]

They are only used for one or two landings.

My recollection from reading and searching last week is the tires are used once ... and if inflated to 300 PSI 'on the ground' the 'pressure' difference the tires would see from sea level (sea level = approx 14.7 PSI) and the pressure at altitude would represent a mere drop in the bucket -

- tire pressure measured on the ground: 300 PSI guage or 314.7 PSI absolute, in space 'guage' and absolute would be the same or 314.7 PSI ...

[NormsRevenge]

Tell me you're kidding. They launch and land with inflated tires, knowing that leakage, pinholes, etc in the wing structures could occur?

That sounds risky to me, for some reason. It assumes you have high confidence in maintaining a pressurized environment in the wheel well areas, where you also assume, lies your greatest risk of damage, in the likelihood a breach could occur. JMO