No, Lott is a big States Rights advocate, as are many southerners. This goes back to the Civil War, and is often misconstrued with segregation and racism.
In todays society, this mis-perception is simply not true, and it was only partly true then.
The southern states wanted the freedom to determine their own destiny regarding many issues that they felt the federal government was infringing on.
Slavery was but one of them then and is not even considered now.
I might be willing to believe you if Lott had ever actually tried to oppose legislation based on the tenth amendment. Lott is as guilty as any of pork-barrel politics. He never objected to mandating that citizens of one state pay for a school building in another state (i.e. "the Trent Lott Middle School of Pascagoula Mississippi). Those in the south (like me) who are states rights supporters want our state legislatures to reclaim the powers (willingly given up) that they gave to the fed's.