These are all truly lost souls until or unless someone or something breaks through their walls of denial. Interestingly enough, I've seen polls which indicate fully 70% and up from the pro-abortion side of the argument agree that abortion is murder. But then they say, in effect, "So what?"
I would like to respectfully disagree with your contention that this is "blasphemy of the Holy Spirit." That blasphemy was the attribution of the works of God to Satan...contending that Satan had performed certain works of power when in reality it had been the work of Jesus Christ.
I believe the more correct reference you are looking for is the "hardening of the heart" or the "searing of the conscience" - reaching a state where the conscience is no longer a guide to righteousness.