Haven't seen the movie yet, but I have no doubt McGuire is terrific in the movie. This is a good time to recommend another McGuire movie, the little-seen gem Ride With The Devil
McGuire IS very good in Spider-Man, and so are Defoe and Dunst (and I usually think she has a face that's about a half size too big), but my pick for the outstanding performance was the actor -- whoever the heck it was -- who played the Green Goblin's son. Does anyone know who it was? He had to play friendly, but not pushy; rich and empowered but not obnoxious; attractive to gals, but not a winner... And he carried off the part great.
Mark W.