McGuire IS very good in Spider-Man, and so are Defoe and Dunst (and I usually think she has a face that's about a half size too big), but my pick for the outstanding performance was the actor -- whoever the heck it was -- who played the Green Goblin's son. Does anyone know who it was? He had to play friendly, but not pushy; rich and empowered but not obnoxious; attractive to gals, but not a winner... And he carried off the part great.
Mark W.
Harry Osborn was played by James Franco. I thought he did a fine job too.
I did a search and found out he also played James Dean in a TV bio. Won a Golden Globe for TNT's made for TV movie. I thought he looked familiar.