I don't know about your particular situation, but I see deal-killing mistakes in resumes every day.Some common mistakes: a virus or compressed resume, a resume in MS Word format instead of text, a jack-of-all trades resume, a resume that includes "reasons" why you aren't currently employed, a resume that makes it appear as though you are currently employed when you really aren't, a lack of references, and lack of a cover letter.
Of course, the biggest deal-killer is upsizing. You would be amazed at how many resumes my firm gets from laid-off techies (e.g. programmers, DBA's, and system administrators) wanting to be "managers".
Suffice it to say that when you are unemployed is NOT the time to be trying to give yourself a promotion.
TIPS on getting hired: include in your cover letter your willingness to relocate, travel, and work overtime. Name your salary and make sure that it is LOWER than the industry average for your skillset. Pricing yourself out of the job market is NOT the thing to be doing when you are unemployed. Once you are in the door, THEN negotiate a market rate (it will be easy at that point, too, since you came in below the industry average).
In your resume, make certain that it is specific. If you are a Java programmer, detail your Java training, tools, and related experience. Omit non-Java descriptions (such as a brief system administration position that you may have held while Lucy was on maternity leave, et al).
Show a progression. Your experience should show that you started as an entry-level junior programmer, put in your time and became a Java analyst, and was later promoted to team lead. If there is no progression, then any claims to being a "lead programmer," "senior programmer," or "project lead" will be discounted. If your resume shows that you held a confusing array of positions, then you will be at the bottom of the stack for every hiring manager in the country. Your resume is NOT the place to advertise Attention Deficit Disorder. Listing ten jobs in five years plus a 6 month "sabatical" is not going to get you the right kind of hiring attention (unless, of course, it is for a fixed-length temporary contract position).
In short, when you are laid off and WANT to get hired quickly, insure that your cover letter spells out attractive terms, that your references are included up front (naturally, you've already contacted them so that they know to expect reference checks), and name your specialty. Your resume should be focused on your specialty, and you should not be trying to give yourself a promotion (e.g. to a project manager from a programming position) or a raise.
There is a triangle which can help point out the big picture. "Timing" is on top of the triangle, "Location" is on the left, and "money" is on the right. An educated, experienced, non-felon in America can always get a job that gives you one of those conditions. Really good or lucky people can get any two of those options. The unemployed are those who insist upon all three...
Good luck!