Which items in the domestic agenda do you mean?
The second half of his State of the Union Address, all of the big government programs, the education bill, fetal stem cell research (he got suckered), airport security, his failure to take many necessary steps to secure our borders, his ongoing attempts at amnesties for illegals by other names.
On the positive side is the Tax Cut and his efforts to privatize some aspects of Social Security (huge kudos). Also chucking some of Clinton's last minute enviro regs, trying to open up Alaskan oil, hammering the Dems on judicial appointments (though I'd have liked to seen it come sooner.
Those are off the top of my head, and not an exhaustive list.