"Yes. Not even yes, but of course. That is the entire crux of the matter. "
The sequence is the info. Change them and it is completely different." - tallhappy
Can we agree that Watson's math applies to the sequencing of data?
Who's Watson?
It doesn't apply to the sequencing of chemical bonds at the molecular level. Certain elements bond, others don't. If you have molecules of carbon, oxygen, argon and krypton floating around together, the carbon will bond with the oxygen, not with the argon or krypton. If Watson's math assumes that any molecule has an equal chance of bonding with any other molecule, it is not valid for predicting the odds of certain chemical reactions occurring.
To answer your fundamental question, yes. Mathematical analysis of sequence information is relevant and practical.
If anyone is trying to argue it is not, then they are mixed up. If they are trying to argue a specific analysis is incorrect, that's another issue.
I know how this always breaks down. One person says the odds of the complex nature of the bacterial genome occuring are so high as to be impossible, much less the human genome.
The mat can be argued about. The response is usually the vast amounts of time that allowed the odds to be overcome.
Here is how it ultimately breaks down.
Atheist says no matter what the odds are, it happened, therefore it isn't impossible.