The 14th Amendment clearly states that the priveledges and immunities of one state can not be denied to those in other States. Therefore, that means laws must be uniform. I can not be deemed a "criminal" for simply crossing into a different geographical area. See, California legalized pot for medicinal uses. IF we followed the Constitution, then it would be de facto legal everywhere, since the "privelegdes and immunities" of the citizens of California can not be denied to others. See, if only actions that were an initiation of force or fraud were deemed "criminal", then there would be no problem at all.
States only have rights in relation to the federal government. In relation to individuals, they have powers.
States rights in the first case, (which really are just limitations on the power of the federal government, in other words, reserving powers to themselves,) are never rightfully allowed to usurp individual rights.