The only open entrance to the Building is on "C" Street, SW, between 3rd and 4th Streets.
It is directly across 3rd Street from the Hubert Humphrey Building, which is the HQ Building for the Department of Health and Human Services.
It is directly across "C" Street, SW, from the Mary Switzer Federal Building, which houses the Department of Education and other HHS Offices.
It is diagonally across the intersection of 3 and C Streets, SW, from the FDA Building.
The closest Metro Stop is Federal Center, SW, on the Blue and Orange Lines.