Posted on 11/03/2022 12:54:36 PM PDT by Right Wing Vegan
An international team of researchers led by scientists at UC San Diego School of Medicine have shown that the virus which causes COVID-19 can damage brain cell synapses, according to a report published Thursday.
By using tiny, self-organized, three-dimensional tissue cultures derived from stem cells called organoids, the scientists found that the SARS- CoV-2 virus infects cortical neurons to damage and destroy the synapses — the connections between brain cells that allow them to communicate with each other.
“Vaccines and emerging treatments have reduced the health consequences of COVID-19 in most patients,” said senior study author Alysson R. Muotri, professor in departments of pediatrics and cellular and molecular at UCSD School of Medicine. “But the phenomenon of Long COVID, characterized by persisting symptoms that include neurological impairment, remains poorly understood and without any specific remedy.
“This work helps explain some of the neurological symptoms of COVID- 19 and, more importantly, it suggests that an FDA-approved antiviral drug might be repurposed to restore infected brain cells to health and address long-term neurological outcomes of COVID-19,” Muotri said.
The findings, published in Thursday’s issue of PLOS Biology, report the antiviral drug sofosbuvir — already an approved treatment for hepatitis C – – effectively inhibited SARS-CoV-2 replication and reversed damages in infected brain organoids. Organoids can mimic some organ functions.
According to the researchers, though primarily considered to be a respiratory disease, COVID-19 can cause temporary or long-lasting neurological symptoms in some patients, ranging from loss of taste and smell, brain fog, and psychological effects such as depression to stroke, epilepsy and a change in brain function or structure.
Researchers exposed the brain organoids to the virus, observed viral infection and replication and noted that the virus rapidly decreased the number of excitatory synapses in neurons within seven days post-infection. Excitatory synapses increase the firing action potential of a neuron, while their counterparts — inhibitory synapses — decrease that potential.
When infected organoids were treated with sofosbuvir, the researchers observed the viral replication was inhibited and neurological impairments were rescued or restored. According to the team, these findings echo earlier models that suggested sofosbuvir could be a treatment and previous research by Muotri and colleagues that found sofosbuvir effectively protected and rescued neural cells infected by the Zika virus.
“The bottom line is that sofosbuvir appears to have the potential to arrest or prevent the development of neurological symptoms in COVID-19 patients,” Muotri said. “And because it has been shown to present no safety concerns in pregnant women, it might also be an option for preventing SARS-CoV- 2 transmission to their unborn children.
“Further studies and clinical trials are needed, of course, but these findings offer a path forward for treating a condition (Long COVID) that has so far stymied remedy for millions of people wordwide,” she said.
Uh, I think I'll pass. Thanks but no thanks.
Excrement. THEY will be using many ploys to deflect from the vax as the cause. Long covid etal.
What happens in tissue culture does not immediately translate into in vivo responses to the virus.
You cannot make policy from one publication.
That’s why we still have animal testing.
“Vaccines and emerging treatments have reduced the health consequences of COVID-19 in most patients,” said senior study author Alysson R. Muotri, professor in departments of pediatrics and cellular and molecular at UCSD School of Medicine.
You obviously have never had the Covid disease or you wouldn’t so easily dismiss the rather obvious and universal long lasting effects such as taste, smell, concentration and other brain function conditions that never existed before getting the Covid disease but which clearly Manifest in most people after acquiring the ailment.
While the disease in most people is very mild and not life threatening there is a distinct set of symptoms that accompanied the infection and take a long time to disappear, if they ever do.
“Scientists Find COVID Damages Brain Cell Synapses, But Propose Treatment”
Let me guess-—the vaccine and Plaxovid. Because they definately don’t damage the body at all-—no sir.,
I’ll pass on their “treatment” but agree on their observation of what covid does to you. I had it back in May and was mentally foggy for like six weeks afterwards.
You are correct about the lasting effects of the China virus.
“but which clearly Manifest in most people after acquiring the ailment.”
we know dozens of ppl who were sickened by covid, both vaxed and not vaxed, and not one of them has reported long term effects ...
So no one has said they have intermittent taste or smell issues, brain fog, memory lapses and the like?
Every one that I know has said they have experienced one or more of these symptoms. They initially are so minor and unidentified that most people may not recognize they have them until they actually have to think about it. It is easy to say you have no long term issues but that is not what the vast majority of people are reporting.
Since the science clearly indicates that these symptoms occur, to one extent or mother, my guess is some people just don’t recognize them.
“but that is not what the vast majority of people are reporting.”
when you say “vast majority”, what is your sample size?
True, but now we are the animals!
TOO LITTLE
TOO LATE
Either it’s the vax and Big Pharma needs to pay or it’s real and now that congress says covid came from the Wuhan lab, China needs to pay.
The long term death toll will be in the billions.
I wonder, in a few years, will the web be wiped of all mention of the Georgia Guidestones? They’re already physically gone. Just need to wipe the digital memory banks and pretend they never existed. I suppose they’re mentioned in a few older books.
I ended up agreeing to undergo a procedure called transcrainal magnetic stimulation (TMS) with exceptional results. It is also used to treat PTSD, glad I had a doctor who was willing to go above and beyond.
Much of the long Covid came from treating it with Remdisivir.
The literature on the subject seems quite clear.
Let me guess, the answer is BOOSTERS. LOTS of “boosters”.
“The literature on the subject seems quite clear.”
i see ... what literature?
if you can’t provide us some links, then we know you’re just making shite up ...
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