The Pilgrims/Separatists got along well with the Wampanoag for a while. After Massasoit died the relationship went downhill. There were a lot more English showing up by then and not all of them wanted to get along with the Indians.
Massossoit’s son also became belligerent to the Pilgrim’s religion and private ownership of the land
http://mayflowerhistory.com/massasoit
Caleb Johnson has one of the most well known Mayflower and Plymouth websites among New England genealogists. We’re from the Plymouth area and my sister did our genealogy. I got into it for a while too. I had a good library with a genealogy section nearby and used to look things up for my sister and also traced our surname back to a 1630 arrival of a ship to what’s now Boston. The surname morphed a lot over the years but started out as Pollard, my screen name. We have several lines going back to the Mayflower passengers by way of marriages.
When you look at an ancestral chart of Pilgrim descendants back in the 16-1700s, it looks like something you’d see in back woods Mississippi with lines that criss cross with people marrying 4th cousins twice removed etc.
There are an estimated 35 million mayflower descendants these days.