...and it kills or cripples the other 5%???
That's all they test for in phase 1. Not efficacy, just safety. If it killed or crippled anyone they would not have proceeded to phase 2.
And if it failed, do you think that we’d know it?
...and it kills or cripples the other 5%??? That's all they test for in phase 1. Not efficacy, just safety. If it killed or crippled anyone they would not have proceeded to phase 2.
Other way around - Phase 1 is efficacy. If it doesn't work it doesn't go to Phase 2. Phase 2 is to assess best dose / dose frequency. Phase 3 is safety and efficacy.
There is Phase 4 post-marketing for more safety and efficacy data.