If whoever Trump nominates does not receive 50 votes in senate, there is no time left for a do-over. Your next SCOTUS justice could be a Biden nominee.
If RBG had kicked the bucket 6 months back, there would have been time available for multiple fights for more than one nominee.
You stick with fundamentals and use any means possible to destroy your opponent (Even within your political Party). Thune better get his ass in gear and start whipping the crap out of the Senate Republicans.