Posted on 04/21/2020 2:49:58 PM PDT by Magnatron
Coronavirus patients taking hydroxychloroquine, a treatment touted by President Trump, were no less likely to need mechanical ventilation and had higher deaths rates compared to those who did not take the drug, according to a study of hundreds of patients at US Veterans Health Administration medical centers.
The study, which reviewed veterans' medical charts, was posted Tuesday on medrxiv.org, a pre-print server, meaning it was not peer reviewed or published in a medical journal. The research was funded by the National Institutes of Health and the University of Virginia.
In the study of 368 patients, 97 patients who took hydroxychloroquine had a 27.8% death rate. The 158 patients who did not take the drug had an 11.4% death rate.
"An association of increased overall mortality was identified in patients treated with hydroxychloroquine alone. These findings highlight the importance of awaiting the results of ongoing prospective, randomized, controlled studies before widespread adoption of these drugs," wrote the authors, who work at the Columbia VA Health Care System in South Carolina, the University of South Carolina and the University of Virginia.
Researchers also looked at whether taking hydroxychloroquine or a combination of hydroxychloroquine and the antibiotic azithromycin, had an effect on whether a patient needed to go on a ventilator.
(Excerpt) Read more at cnn.com ...
How do you know that Zelenko is telling the truth and the Veteran's Administration is lying?
More from the actual study:
“Compared to the no HC group, there was a higher risk of death from any cause in the HC group (adjusted HR, 2.61; 95% CI, 1.10 to 6.17; P=0.03) but not in the HC+AZ group”
So again, HC_+AZ = less death. The authors are deliberately disingenuous with their findings versus the actual data.
Yak... yak... yak... if someone does not want to take the drug, and die... who cares? If others want to discuss the matter with their doctors, that’s fine too. I’d prefer a pill over a plastic tube shoved down into my lungs.
Some additional things that need to be understood about this non-peer reviewed study:
The study does not query or document why the VA doctors chose the regimen of care for their COVID positive patients. So for example, if doctors felt a patient was in a desperate condition and they therefore initiated HCQ as opposed to a non-severe case where the doctor chose no drug therapy those are treated as equally at risk cases.
That is plainly a flaw in the study and ought to be acknowledged.
I know they lie ALL THE TIME.
THAT IS ALL I need to know about it
Patients not given hydroxycloroquine WITH zinc should organize a class-action malpractice suit asap.
Here is the conclusion of the study:
“This work was supported by National Institutes of Health (USA) grants (R01EY028027 and R01EY029799), DuPont Guerry, III, Professorship, and University of Virginia Strategic Investment Fund to JA. The funders had no role in study design or conduct, data collection, analysis, or interpretation, manuscript writing, or the decision to submit the manuscript for publication. The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health, U.S. Department of Veterans Affairs, nor does mention of trade names, commercial products, or organizations imply endorsement by the United States government. This paper represents original research conducted using data from the Department of Veterans Affairs and is, in part, the result of work supported with resources and the use of facilities at the Dorn Research Institute, Columbia VA Health Care System, Columbia, South Carolina.
Disclosure forms provided by the authors are available with the NEJM. JA is a co-founder of iVeena Holdings, iVeena Delivery Systems and Inflammasome Therapeutics, and has received consultancy fees from Allergan, Biogen, Boehringer Ingelheim, Immunovant, Janssen, Olix Pharmaceuticals, Retinal Solutions, and Saksin LifeSciences, all unrelated to this work. JA is named as an inventor on a patent application filed by the University of Virginia relating to Covid-19 but unrelated to this work. SSS has received research grants from Boehringer Ingelheim, Gilead Sciences, Portola Pharmaceuticals, and United Therapeutics, all unrelated to this work. The other authors declare no competing interests.”
Cut to the chase, Gilead sciences helped fund the study as did the University of Virginia that is also investing in COVID solutions. So, these interests would both profit mightily if an inexpensive therapy like HCQ+AZ+zinc were found to NOT be therapeutic. Authors conclude: “we have not competing interests.”
False.
By the way, I am fine with institutions seeking other solutions but we should not pretend this was a dispassionate or fair analysis.
Authors also concede this in the conclusion:
“Our study has certain limitations including those inherent to all retrospective analyses such as non-randomization of treatments. “
That is exactly what I said in an earlier post that we do not know the conditions under which these three different treatment options were pursued.
I would bet money that there exists within the database instances of using the full protocol of three recommended medicines and the authors chose not to include that data.
According to whom?
By the way, I am also glad that magnetron posted this because I agree we need to be ready for the enemy and posts like these help us deconstruct the problem.
Meanwhile the many who have been saved by the drug can give a big F U to the commie media..notice the only drug the commie media is rooting for is Remdesivir, want to know why, because Remdesivir costs 1,000 per pill, hydroxy is 5 cents per pill its ALL about the money, that and a vaccine..gee if Hydroxy is SO dangerous I guess take it off the market, why should lupus patients die from such a horrible drug right commie media
Nothing like facing death and seeing that there may be a remedy knowing it may not be 100% (no drug is) but it out weighs the risk of certain death but it is denied for POLITICAL reasons.
Here is a link to the study
https://www.medrxiv.org/content/10.1101/2020.04.16.20065920v1
This retroactive study means nothing as there is no control over random assignment of patients who were assigned to a treatment group or non treatment group.
So the patients who were not sick enough to receive treatment had lower mortality rate.
DUH!!!
It’s like saying that cancer patients who were at advanced stages and received chemo were more likely to die.
CNN has nothing on the National Enquirer. /s
Yes. The control should be those who would normally be proscribed HCQ but we’re not...what was their mortality rate.?
Without this then the study is simply reporting the results rather than efficacy.
These people are just sick. They are celebrating a possible cure for the disease doesn’t work. Let’s hope they are wrong but the idea that a cure does not work is good news because it means Trump does not get a win is just deranged.
It was not a study. They just took the statistics from VA. They have no idea why any of the people were put on drugs, or why they were not.
Most likely is, the sicker a person was, the more likely they ended up on HC or HC+AZ, subject to the laws of whatever state they were in, and whether one or both of the drugs were available.
My guess is the group that didn’t take the drugs were the least sick, why would you take an experimental drug if you feel fine anyway?
This is not a PR battle. Trump said this drug might be helpful, and if it is, that would be great.
In the next month or two, we will get the conclusions from some real studies.
If the drug doesn’t work, we want to know that.
If the drug does work, all the spin in the world won’t “trump” the actual test results.
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