The risk is actually quite small since even if we lose a few seats, the GOPe Senator will be history...and there is little the Republicans have done to further our cause.
As for Judges, Trump can still make the nominations he sees fit and stand pat.
No compromise.
Fill the seat with a Trump nominee or it goes unfilled for the duration of his time in office.
No loss.
Don’t weaken and adopt the fear-mongering tactics of the Republicans.
Look at Pennsylvania, for example. One of the most astonishing things we saw in 2016 is that President Trump managed to win that state even while a moderate Republican like Pat Toomey also won (they appealed to two very different voter groups). I don't see any situation where I'd be happy with Toomey losing that election, even if I would have preferred someone else running in his place.