I did that a few months back. Big Boy in .44Mag. Topped with receiver mount peep sight from Skinner Sights. The 240 gr JHC has a pretty stout recoil and you have to be careful about only filling the tubular mag with the lever closed. Should be a fine deer rifle.
One caveat with the Skinner Express sight. The elevation with the stock sight is off. You need to swap the front blade too. I need to take mine out to a 100 yard range and get a more precise measurement. It will be a filing job to finish the task. Stock one is too short. Shoots high. Replacement will be too tall and shoot low. A little filing will bring it in. The peep really improved my groups. Be sure to view to video on the Henry site for doing the field strip for cleaning. I was unfamiliar with the process for a Henry.