Well...
Before 1492, the people of the Americas were the terrorists.
They lived in a near constant state of war, and human sacrifice and cannabalism was common.
The difference after 1492 was that new tribes, with a higher levels of technology entered the arena. The new tribes were from further away, so they carried germs the tribes in the Americas did not have.
Every inch of soil in the Americas was conquered and reconquered many times before any significant number of Europeans ever set foot in the Americas.