That’s like saying in 1940 “if the UK were to fight Nazi Germany by itself, it’d be consigning itself to historical irrelevance.”
Correct. Britain should retain their autonomy... Strength and individualism.
A brexit would be akin to the UK saying in 1940 "we will be neutral" -- a UK outside the EU has no ability to influence the EU and many EU member states (like POland, Hungary) have looked at the UK as a way to balance the Franco-German axis
If Brexit happens, then SCotland will break away and you will have just England (Welsh nationalists would also break away, albeit reluctantly) -- England would be a small country with no agricultural or manufacturing base and heavily reliant on financial services -- and those financial services will move away: to european bourses and to Dubai, Singapore, Hong Kong and New York
The UK would be consigned to further slip into irrelevance -- like Rome in the 12th century...