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To: WhiskeyX

Okay sorry I just re-read please ignore my previous question. It’s early for me. I’ve tested with somewhat higher than normal androgen levels, although I didn’t develop any symptoms of that until maturity, specifically during a pregnancy. It just makes me wonder what went wrong and when? I’ve heard of CACH but not the thing you mentioned.


39 posted on 10/09/2015 5:28:48 AM PDT by kelly4c (http://www.freerepublic.com/perl/post?id=2900389%2C41#help)
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To: kelly4c

“I’ve tested with somewhat higher than normal androgen levels, although I didn’t develop any symptoms of that until maturity, specifically during a pregnancy.”

To understand what AIS and CAIS are see the Wikipedia article (CAUTION NUDITY):

Complete androgen insensitivity syndrome

Complete androgen insensitivity syndrome (CAIS) is a condition that results in the complete inability of the cell to respond to androgens.[1][2][3] The unresponsiveness of the cell to the presence of androgenic hormones prevents the masculinization of male genitalia in the developing fetus, as well as the development of male secondary sexual characteristics at puberty, but does not significantly impair female genital or sexual development.[3][4] As such, the insensitivity to androgens is only clinically significant when it occurs in genetic males (i.e. individuals with a Y chromosome, or more specifically, an SRY gene).[1] All affected individuals are phenotypically female; they develop a normal female habitus, despite the presence of a Y chromosome.[1][5][6][7][8][9]

CAIS is one of three types of androgen insensitivity syndrome, which is divided into three categories that are differentiated by the degree of genital masculinization: complete androgen insensitivity syndrome (CAIS) is indicated when the external genitalia is that of a normal female, mild androgen insensitivity syndrome (MAIS) is indicated when the external genitalia is that of a normal male, and partial androgen insensitivity syndrome (PAIS) is indicated when the external genitalia is partially, but not fully masculinized.[1][2][5][6][7][10][11][12][13]....

Androgen insensitivity syndrome is the largest single entity that leads to 46,XY undermasculinization.[14]

https://en.wikipedia.org/wiki/Complete_androgen_insensitivity_syndrome

Another article about the genetics which result in AIS, CAIS, and other intersex conditions:

Does having a Y chromosome make someone a man?
http://www.isna.org/faq/y_chromosome


52 posted on 10/09/2015 10:21:33 AM PDT by WhiskeyX
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