Which came first, prohibition or repeal of prohibition?
First? First was each state deciding whether or not to legalize alcohol. And the result was a 50-50 split among the states.
Of course that didn't work since the "wet" states smuggled booze to the "dry" states. So, at the request of the states, Congress passed the Webb-Kenyon Act making that smuggling illegal. That didn't work either.
Then came Prohibition. Alcohol use actually increased every year during Prohibition, and there were more speakeasies during Prohibition than there were bars before it. Turns out, the people didn't really want Prohibition and they repealed it at the national level.
Are you saying we should ignore history and have each state decide on the legality of drugs? Do you expect a different outcome? Do you care?