We have in the case of the first 150 or so years of the USA another example of what happens when you *DON'T* make certain substances illegal: not much.
And here you are lying again. Once again you trot out this LIE and try to get by with it again.
This is a total and complete misstatement of the truth and it is part and parcel of the continuous stream of lies which Libertarians always trot out to justify their delusions.
There were no laws against drug use because there was very little and highly isolated usage during this period of history. It's like saying there wasn't any cybercrime back then so we don't need laws against cybercrime now.
It was the Civil war that introduced the US to large quantities of drugs and large quantities of addicts, the consequences of which kept getting worse until they finally had to pass laws against drugs.