[Smokin' Joe]

This reeks of the Tuskegee Experiment sort of horrorshow for science mentality.

How about this?

All around the group who gets the vaccine will be your control group: those who do not. No placebo necessary. Compare those stats and if there isn't a significant difference the vaccine didn't work.

[Calvin Locke]

One breast cancer drug that was in a double blind study had early results were so promising, at least for what it was intended, that they came to the conclusion that it was unethical to continue with a placebo as part of the trials.

I have a relative that was in a trial for some drug for a while. He was taking the drug to begin with, before being asked to participate in the trial.

He knew he had the placebo in the trial because it didn't cut/break in half the same way as the real stuff.