NH would be a great pickup.
| State | Republican | R% | Democrat | D% | O% | Margin | Cur | New | Chg |
| Alabama | Jeff Sessions ( i ) | 87.1 | none | 0.0 | 12.9 | 87.1 | R | R | |
| Alaska | Dan Sullivan | 51.6 | Mark Begich ( i ) | 44.0 | 4.4 | 7.6 | D | R | + |
| Arkansas | Tom Cotton | 55.1 | Mark Pryor ( i ) | 40.4 | 4.5 | 14.8 | D | R | + |
| Colorado | Cory Gardner | 51.7 | Mark Udall ( i ) | 42.6 | 5.7 | 9.1 | D | R | + |
| Delaware | Kevin Wade | 43.5 | Chris Coons ( i ) | 55.2 | 1.3 | (11.8) | D | D | |
| Georgia | David Perdue | 49.2 | Michelle Nunn | 47.3 | 3.5 | 1.9 | R | r/o | |
| Hawaii | Cam Cavasso | 29.5 | Brian Schatz ( i ) | 69.6 | 0.9 | (40.2) | D | D | |
| Idaho | Jim Risch ( i ) | 64.1 | Nels Mitchell | 35.9 | 0.0 | 28.2 | R | R | |
| Illinois | James Oberweis | 45.3 | Dick Durbin ( i ) | 54.2 | 0.5 | (8.9) | D | D | |
| Iowa | Joni Ernst | 52.1 | Bruce Braley | 46.0 | 1.9 | 6.1 | D | R | + |
| Kansas | Pat Roberts ( i ) | 48.7 | Greg Ormand | 48.9 | 2.4 | (0.2) | R | D | - |
| Kentucky | Mitch McConnell ( i ) | 50.6 | Alison Grimes | 45.7 | 3.7 | 4.9 | R | R | |
| Louisiana | Bill Cassidy | 44.1 | Mary Landrieu ( i ) | 43.1 | 12.8 | 1.1 | D | r/o | |
| Maine | Susan Collins ( i ) | 62.3 | Shenna Ballows | 33.1 | 4.6 | 29.2 | R | R | |
| Massachusetts | Frank Addivinola | 40.8 | Edward Markey ( i ) | 57.2 | 2.0 | (16.4) | D | D | |
| Michigan | Terri Lynn Land | 44.9 | Carl Levin ( i ) | 52.9 | 2.2 | (7.9) | D | D | |
| Minnesota | Mike McFadden | 40.9 | Al Franken ( i ) | 55.3 | 3.8 | (14.3) | D | D | |
| Mississippi | Thad Cochran ( i ) | 55.2 | Travis Childers | 36.7 | 8.1 | 18.5 | R | R | |
| Montana | Steve Daines | 59.5 | Amanda Curtis | 38.9 | 1.7 | 20.6 | D | R | + |
| Nebraska | Ben Sasse | 73.6 | Dave Domina | 20.8 | 5.6 | 52.8 | R | R | |
| New Hampshire | Scott Brown | 50.3 | Jean Shaheen ( i ) | 48.2 | 1.5 | 2.1 | D | R | + |
| New Jersey | Jeff Bell | 41.5 | Cory Booker ( i ) | 56.6 | 1.9 | (15.1) | D | D | |
| New Mexico | Allen Weh | 44.2 | Tom Udall ( i ) | 54.6 | 1.2 | (10.4) | D | D | |
| North Carolina | Thom Tillis | 50.5 | Kay Hagan ( i ) | 42.9 | 6.6 | 7.6 | D | R | + |
| Oklahoma | Jim Inhoffe ( i ) | 67.7 | Matthew Silverstein | 29.7 | 2.6 | 38.0 | R | R | |
| Oklahoma | Jim Lankford | 72.2 | Connie Johnson | 26.5 | 1.3 | 45.7 | R | R | |
| Oregon | Monica Wehby | 44.3 | Jeff Merkley ( i ) | 51.0 | 4.7 | (6.7) | D | D | |
| Rhode Island | Mark Zakaria | 34.5 | Jack Reed ( i ) | 65.4 | 0.1 | (30.9) | D | D | |
| South Carolina | Lindsey Graham ( i ) | 56.1 | Brad Hutto | 36.6 | 7.3 | 19.5 | R | R | |
| South Carolina | Tim Scott ( i ) | 61.7 | Joyce Dickerson | 38.2 | 0.1 | 23.4 | R | R | |
| South Dakota | Mike Rounds | 47.5 | Rick Weiland | 33.3 | 19.2 | 14.2 | D | R | + |
| Tennessee | Lamar Alexander ( i ) | 59.6 | Gordon Ball | 38.7 | 1.7 | 20.9 | R | R | |
| Texas | John Cornyn ( i ) | 59.5 | David Alameel | 39.7 | 0.7 | 19.8 | R | R | |
| Virginia | Ed Gillespie | 46.9 | Mark Warner ( i ) | 51.1 | 2.0 | (4.3) | D | D | |
| West Virginia | Shelley Moore Capito | 61.5 | Natalie Tennant | 37.5 | 1.0 | 24.1 | D | R | + |
| Wyoming | Mike Enzi ( i ) | 77.1 | Charlie Hardy | 20.3 | 2.6 | 56.8 | R | R |