I have a friend who has done business in Scotland for years and used to have a facility there. He just returned from a two week trip this week and says if this vote passes the negative financial impacts will be huge - not just there but rippling all over the world.
I seriously doubt it. Scotland has less than 10% of the UK's population. England will get on fine without Scotland (and Wales and Northern Ireland). Much of the English Crown's expansion into the rest of what came to be known as Great Britain was a way to forestall recurrent raids by the Welsh, the Scots and the Irish into England, the most fertile and productive part of the realm. The other part of England's rationale for dominating the British Isles was to deny the continental powers a staging area for the invasion of England. Today, the only thing the continental powers are marching towards is welfare state insolvency.
The EU especially does not like citizens getting ideas of self determination. They like citizens obeying instructions from non elected bureaucrats.