I never tried it and have no plans to, I think it smells awful.
I know people that use it that are fine responsible citizens (like a couple of my uncles!) and others that are not like the jagoff tenants my father just had to evict.
I would gather that using a lot of it clearly **cks up the brain somehow. More or less than booze? I don’t know. Probably about the same. I’d advise anyone that uses it to practice moderation.
I’m not a drug warrior type but I expect negative social effects to manifest themselves in Colorado.