I think they are at war with God and man.
Genesis 16:10-12 (NIV, © 2011) 10 The angel added, “I will increase your (Hagar, slave of Sarah and wife of Abraham) descendants so much that they will be too numerous to count.” 11 The angel of the Lord also said to her: “You are now pregnant and you will give birth to a son. You shall name him Ishmael, for the Lord has heard of your misery. 12 He will be a wild donkey of a man; his hand will be against everyone and everyone’s hand against him, and he will live in hostility toward all his brothers.”