Nah. Fire 3x cruise missiles at each US destroyers. From 1/2 mile out. No warning. Just launch. Don't even bother to wonder if the cruise missile arms itself. Just hit the destroyer or supply ship (they are the only ones we have in the Med) with the mass of the weapon itself.
Power. Computers. Weapons. Mobility. Structure damage. Engine room and GT intakes out. Radio out. Radars out. Missile launchers out. CIC out. Ship is worthless from the impact damage alone.
No cruiser or destroyer-sized ship hit by ANY single weapon of ANY kind (whether armed or dud) in ANY action or accident since WWII in ANY navy worldwide has had command, control, combat capability and mobility survive after the impact. NONE. In ANY navy. (Above based on over two dozen accidents and combat hits.) Now, many of the ships hit "only" a few of the above ("only" losing all electric power for a "only" few hours, or "only" getting their keel blown in half, or "only" losing their weapons or "only" their magazine or "only" their radar and radio or "only" shaft and steering. But NONE could keep fighting.