[The Comedian]

It's too bad that VD is a mystery disease, and we have no idea how it is transmitted, or we could tell people to quit doing whatever was vectoring the disease.

But just like the cause of Sudden Jihad Syndrome, or how Whoopi Goldberg got into show business, we will never know...

Frowning takes 68 muscles.
Smiling takes 6.
Pulling this trigger takes 2.
I'm lazy.

[Disambiguator]

...how Whoopi Goldberg got into show business

She obviously had someone's favorite fantasy all figured out.