I use Federal 230Gr +P Hydro Shock in my 45 ACP. That should take them off their feet if needed!
Exact same set up here — my .45 eats that ammo like there’s no tomorrow. Smooth as silk.
Why have a .45? Cause shooting twice is a waste of effort!
Seriously, anything over a .357 mag will do the job with one well placed hit, but if you’re shooting a 9mm or .380, having Hornady CritDs or XTPs helps!