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Tracing amyloid in Alzheimer's
Chemistry World ^ | 14 October 2009 | Phil Taylor

Posted on 10/15/2009 12:40:26 AM PDT by neverdem

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1 posted on 10/15/2009 12:40:27 AM PDT by neverdem
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To: texas booster

Ping


2 posted on 10/15/2009 12:49:57 AM PDT by neverdem (Xin loi minh oi)
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To: neverdem

Fascinating.


3 posted on 10/15/2009 1:05:20 AM PDT by TChad
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To: neverdem

Both of my parents have “old-timer’s” disease, so I’m hoping I don’t get it and start voting Democratic.


4 posted on 10/15/2009 4:15:56 AM PDT by Sender (It's never too late to be who you could have been.)
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To: neverdem

‘florbetaben’

What you get when you let Mush Mouth name the drug.


5 posted on 10/15/2009 4:40:45 AM PDT by TangoLimaSierra (To the left the truth looks Right-Wing.)
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To: neverdem

Bump.


6 posted on 10/15/2009 4:49:05 AM PDT by AdvisorB (Obamatude could be defined by Blago as something tangible, but not quite as tangible as JJJ's offer.)
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To: 1066AD; 11Bush; A.Hun; abner; AbsoluteGrace; Advil; aft_lizard; agooga; ahayes; aliquando; ...
Time for a Folding@home science ping!

Neverdem has posted a topic discussing new research avenues in Alzheimer's Disease.

Bayer has completed stage 2 trials of the drug florbetaben that works as a marker for beta amyloids in the brain, potentially allowing for a new diagnostic treatment that can be performed while the patient is still alive. Of which I am in favor.

Research in an antihistamine that improves Alzheimer's symptoms, a metal chelation therapy that traps copper ions and research into the different types of amyloids for toxicity round out as fantastic post.

*****************************************

The Folding@home team at Stanford University has a couple of updates.

First, the servers will be replaced over the next month or so by a new class of servers EACH having 48 TB of storage. This will help out greatly in keeping work units available.

Second, software upgrades to the core software is planned. Work on the GPU3 project promises speed increases on the high end video cards that some use, a new technique to speed up all cores called Normal Mode Langevin (NML) Dynamics is heading to beta, and work is progressing to allow for “simple” SMP cores in Windows and other systems.

Last, I wont to highlight some of the milestones that folders have hit in the last few weeks:

SazanEyes just hit 10,000,000 points
Klutz Dohanger is back and over 9,000,000 points
NAPA_Laurel and mouser both hit 2,000,000 points this week
Onelife hit 1,000,000 points last week
mschalock, LonePalm and HangThemHigh are all over 800,000 points
sshultz460 just hit 300,000 points
jdowntown is a new folder who has hit 40,000 points

Congrats to all, especially our new folders.

**************************************************

Current versions of clients:

Windows console and system tray: 6.23
Mac OS X: 6.26.3
Linux: 6.02 with a beta for 6.24
Playstation 3: 1.3.1

Thanks to one and all for folding!

For more information on Folding@home and how you can help save lives and advance research, please lookie here:

http://www.freerepublic.com/focus/f-chat/2316710/posts#2

7 posted on 10/15/2009 6:51:38 AM PDT by texas booster (Join FreeRepublic's Folding@Home team (Team # 36120) Cure Alzheimer's!)
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To: 1066AD; 11Bush; A.Hun; abner; AbsoluteGrace; Advil; aft_lizard; agooga; ahayes; aliquando; ...
Time for a Folding@home science ping!

Neverdem has posted a topic discussing new research avenues in Alzheimer's Disease.

Bayer has completed stage 2 trials of the drug florbetaben that works as a marker for beta amyloids in the brain, potentially allowing for a new diagnostic treatment that can be performed while the patient is still alive. Of which I am in favor.

Research in an antihistamine that improves Alzheimer's symptoms, a metal chelation therapy that traps copper ions and research into the different types of amyloids for toxicity round out as fantastic post.

*****************************************

The Folding@home team at Stanford University has a couple of updates.

First, the servers will be replaced over the next month or so by a new class of servers EACH having 48 TB of storage. This will help out greatly in keeping work units available.

Second, software upgrades to the core software is planned. Work on the GPU3 project promises speed increases on the high end video cards that some use, a new technique to speed up all cores called Normal Mode Langevin (NML) Dynamics is heading to beta, and work is progressing to allow for “simple” SMP cores in Windows and other systems.

Last, I wont to highlight some of the milestones that folders have hit in the last few weeks:

SazanEyes just hit 10,000,000 points
Klutz Dohanger is back and over 9,000,000 points
NAPA_Laurel and mouser both hit 2,000,000 points this week
Onelife hit 1,000,000 points last week
mschalock, LonePalm and HangThemHigh are all over 800,000 points
sshultz460 just hit 300,000 points
jdowntown is a new folder who has hit 40,000 points

Congrats to all, especially our new folders.

**************************************************

Current versions of clients:

Windows console and system tray: 6.23
Mac OS X: 6.26.3
Linux: 6.02 with a beta for 6.24
Playstation 3: 1.3.1

Thanks to one and all for folding!

For more information on Folding@home and how you can help save lives and advance research, please lookie here:

http://www.freerepublic.com/focus/f-chat/2316710/posts#2

8 posted on 10/15/2009 6:51:49 AM PDT by texas booster (Join FreeRepublic's Folding@Home team (Team # 36120) Cure Alzheimer's!)
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To: texas booster

BTTT


9 posted on 10/15/2009 7:20:41 AM PDT by E.G.C.
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To: texas booster

BTTT


10 posted on 10/15/2009 7:20:56 AM PDT by E.G.C.
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To: texas booster
SazanEyes just hit 10,000,000 points

He must be cheating...that is INSANE! Did he hack Deep Blue and use it for folding?

11 posted on 10/15/2009 8:44:55 AM PDT by Onelifetogive (Liberals are always one genocide away from Utopia.)
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To: Onelifetogive; David Park
No, SazanEyes has built a couple of computers that use the very fast NVidia GPUs to crunch 24/7.

I think that he only has 8 total computers working for us, but with the new graphics cards each of them will output 4000 - 8000 ppd.

I did a small version of it when I added a $100 NVidia card to one of my systems. Accounts for about half of my points daily.

12 posted on 10/15/2009 9:19:07 AM PDT by texas booster (Join FreeRepublic's Folding@Home team (Team # 36120) Cure Alzheimer's!)
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To: texas booster
I have 2 cheap nVidia cards (in 2 PCs) each putting out about 3500 ppd. (I selected them for low energy usage since I run them at home.)

I also have two SMPs running (each over 1000 ppd - One of those same nVidia machines with a quad processor and a 2 Core 2 Duo notebook.)

13 posted on 10/15/2009 9:57:58 AM PDT by Onelifetogive (Liberals are always one genocide away from Utopia.)
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To: Onelifetogive
2 Core 2 Duo notebook

Core 2 Duo notebook!

14 posted on 10/15/2009 9:59:37 AM PDT by Onelifetogive (Liberals are always one genocide away from Utopia.)
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To: texas booster

Thanks for riding herd on this; good to be apprised of progress arising out of it.

I’m scheduled hit half a million sometime around Thanksgiving.

Haven’t nosed about the forums recently; still hoping for a graphical client that plays well in the sandbox with OpenGL. Meanwhile, console clients continue apace.


15 posted on 10/15/2009 4:57:58 PM PDT by HKMk23 (In the end, life contains only one tragedy: not to have been a saint.)
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To: Sender
Well, you could just kill yourself.

But, someone else would just vote Democrat for you.

16 posted on 10/15/2009 5:00:24 PM PDT by Mr. Lucky
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To: Mr. Lucky

Not neccessary. He can still vote Democrat after death.


17 posted on 10/15/2009 5:01:44 PM PDT by trisham (Zen is not easy. It takes effort to attain nothingness. And then what do you have? Bupkis.)
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To: Mr. Lucky

Yeah, I would just become an ACORN-registered Democratic voter if I stopped living.


18 posted on 10/15/2009 7:17:47 PM PDT by Sender (It's never too late to be who you could have been.)
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To: HKMk23
Take a look at this link

http://protomol.sourceforge.net/

and it may help. F@H is rewriting their internal code to be more extensible and to play better with others.

ProtoMol implementation is one of their big projects and is supposed to help pass older M$ standards and greatly boost computation.

19 posted on 10/15/2009 7:37:53 PM PDT by texas booster (Join FreeRepublic's Folding@Home team (Team # 36120) Cure Alzheimer's!)
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To: texas booster

ProtoMol looks really good. Any timeline on an F@H implementation?


20 posted on 10/16/2009 12:51:33 AM PDT by HKMk23 (In the end, life contains only one tragedy: not to have been a saint.)
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