Canada Issues Alert on Severe Respiratory Disease in Mexico
Silent Human Spread of Swine H1N1 in Southern California
The CDC has promptly released the HA (EPI176470), NA(EPI176472), and M(EPI176471) gene sequences of A/California/04/2009 from 10M (at GISAID). These sequences confirm that the NA and M gene have a Eurasian swine origin, while the HA sequences is North American swine. The presence of S31N in the M gene, which is common in European swine, confers resistance to amantadine and rimantadine. Release of the sequences from the other isolate would be useful to determine how long these viruses have been in human populations.The efficient transmission of swine H1N1 in a human population raises concerns of further evolution and adaptation through the exchange of genetic information with human seasonal flu via reassortment and recombination (including H274Y).
Recombination between swine H1N1 and seasonal H1N1 generated the 1918 pandemic strain, which is cause for concern.
Someone correct me if I'm wrong. H1N1 is a description of the Influenza virus that expresses the main or first described variants of the hemagglutanin and neuramidinase glycoproteins on the surface of these microbes.
HA (EPI176470) is the HemAgglutanin epitope, an antigenic detertimant, designated 176470.
NA(EPI176472) is the NeurAmidinase epitope designated 176472. All corrections are always appreciated. I'm trying to teach myself micro since med school over two decades ago.
Yikes!
And I’ve been concerned about SARS and H5N1!