To use a trivial example, suppose you asked me to sort out all the hearts from a deck of cards. That is a trivially easy task for the average person. But to expect a chance mechanism to sort out the hearts and only hearts from a deck of cards would be unreasonable within a human timeframe.
A rule of thumb is that there are about 10^78 elementary particles in the universe. Probabilities of less than 1 in 10^50 are therefore considered such that they would never happen in the history of the universe for any macroscopic event, as a rule of thumb. But even if we bump the odds to 1 in 10^100, the point is that it is easy for intelligent actors to do things that transcend these odds.
But that’s assuming this isn’t the universe in which it happens.
Looking at a single deck is one thing, but when you have an infinite number of decks, it’s easier for a deck of those to have a specific configuration than if you asked a human to sort one.
And there’s no reason to believe we are not in a universe that has that configuration, as we would not be observing the universe if we were in an inhospitable one.