[Southack]

" Even if they did have TLR-4 it wouldn’t help him because fish have that as well as humans, again consistent with evolutionary theory." - ahayes

Nope. Not consistent with Evolutionary Theory.

Oh sure, Fish have TLR-4, but it does something enormously different in Fish than in humans (or than what TLR does in Coral for that matter).

And rest assured that there is no published version of Evolutionary Theory that explains why TLR-4 should perform endotoxin recognition in some species but not in others.

< cue sounds of desperate Darwinists typing that there are Evolutionary explanations, just none published and linkable and that specific >

[Ha Ha Thats Very Logical]

I think the fact that fish have TLR-4 but use it for something else is evidence for, not against, common descent. The fish immune system recognizes the presence of endotoxins, of course, just using a different mechanism: "Our analysis also suggests that beta-2 integrins, a group of well-conserved ancient molecules, may play a primary role in the LPS recognition by the piscine immune system." Why would we all have the same parts if we were going to use them for different things, unless we all had a common ancestor?

What is it you do think happened?

[ahayes]

And rest assured that there is no published version of Evolutionary Theory that explains why TLR-4 should perform endotoxin recognition in some species but not in others.

You do enjoy making sweeping proclamations on subjects you know nothing about, don't you?

Proteins often have multiple roles. The fish use of TLR-4 (still not understood) may be the primitive state or after divergence the fish may have modified the receptor cascade from the primitive state into the modern state. On the line going to mammals a different role became useful as the primary one.

The ancestral TLR in coral still has not been explored. Contrary to your blind assumption that it is involved in endotoxin recognition, it probably has a completely different role. After all, humans have more than ten TLRs, each with a different function. Only someone completely ignorant of this would demand coral TLR be involved specifically in endotoxin recognition.

Yes, that means you.