There’s no fixed configuartion - the A380 will hold up to 800 people in the catle train version - so the needs of US airlines will be fullfilled also.
In Asia and Arabia where there’s a lot of money bags flying airlines ordered the versions with a bit more emphasis on luxury.
Will it? At one point weight, not size, was tje limiting factor, and I never saw reliable reports that the weight issues had been resolved.