Who (what) is "House"? Not a trick question, I don't watch TV except for Dancing with the Stars.
House is a diagnostician who takes on hard cases. He believes to treat fiirst and ask questions later. If it doesn't work, try something else.
House is a popular show on the Fox Network. It's regular slot is 9:00 on Tuesday.
He is also a very obnoxious maverick both hated and admired.