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To: Tokra
You mean like the different bacteria that have evolved to make themselves immune to anti-biotics? The immunity that wasn't in their genetic code before, but is now?

That is nothing more than pharmacodynamic tolerance. Using bacteriological immunity to drugs is a poor example of "evolution". Now if, in response to a large dose of antibiotics one bacteria changed into another type of bacteria altogether then you may have reason to crow.

179 posted on 07/03/2006 4:36:24 PM PDT by Mogollon
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To: Mogollon

Yeesh. I try and try to stay out of these debates, but...

Pharmacodynamic tolerance is an acquired trait, not a hereditary one.

So you're really, really, wrong. Streptomycin resistance is caused predominantly by a hereditary mutation in the ribosomal S12 subunit gene. When the sensitive population was exposed to this drug, this mutation was strongly selected for as predicted by natural selection. Evolution in action.

But please, if you still disagree, by all means explain precisely how all that we've observed with regards to streptomycin resistance is consistent with pharmacodynamic tolerance.

Feel free to use references from the primary literature.


206 posted on 07/03/2006 7:56:11 PM PDT by staterightsfirst
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