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To: Mogollon

Yeesh. I try and try to stay out of these debates, but...

Pharmacodynamic tolerance is an acquired trait, not a hereditary one.

So you're really, really, wrong. Streptomycin resistance is caused predominantly by a hereditary mutation in the ribosomal S12 subunit gene. When the sensitive population was exposed to this drug, this mutation was strongly selected for as predicted by natural selection. Evolution in action.

But please, if you still disagree, by all means explain precisely how all that we've observed with regards to streptomycin resistance is consistent with pharmacodynamic tolerance.

Feel free to use references from the primary literature.


206 posted on 07/03/2006 7:56:11 PM PDT by staterightsfirst
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To: staterightsfirst

Now you've gone and done it. You asked for evidence. Shame, Shame.


221 posted on 07/04/2006 7:56:10 AM PDT by furball4paws (Awful Offal)
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