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First vaccine to fight bird flu is here
indiatimes.com ^ | May 29, 2005 | Kounteya Sinha

Posted on 05/29/2006 1:48:58 PM PDT by Smokin' Joe

NEW DELHI: A single vaccine can now protect poultry against two of the deadliest killers - bird flu and Newcastle disease.

A team of American biologists have found that inserting a bird flu gene into a popular vaccine that protects poultry against Newcastle disease, leads to resistance against both these viruses within the bird's body. There currently is no vaccine for avian flu.

Developed by Peter Palese, chair, department of microbiology, Mount Sinai School of Medicine in New York City, this new vaccine could, for the first time, offer an alternative to the mass slaughtering that has cost the world's poultry industry millions in lost sales, and also an effective and inexpensive way to vaccinate poultry against bird flu.

Scientists added the gene H5 - one of 16 subtypes of hemagglutinin, a protein that binds the avian influenza virus to the cells it infects, to a commercially available Newcastle vaccine.

When they exposed chicken to lethal doses of the avian influenza virus and the Newcastle virus, birds inoculated with the recombinant vaccine produced antibodies against both viruses, offering protection against both diseases.

(Excerpt) Read more at timesofindia.indiatimes.com ...


TOPICS: Culture/Society; Extended News; Foreign Affairs; Miscellaneous; News/Current Events
KEYWORDS: avianflu; birdflu; h5n1; newcastlevirus

1 posted on 05/29/2006 1:49:01 PM PDT by Smokin' Joe
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To: 2ndreconmarine; Fitzcarraldo; Covenantor; Mother Abigail; EBH; Dog Gone; ...

Ping!


2 posted on 05/29/2006 1:49:47 PM PDT by Smokin' Joe (How often God must weep at humans' folly.)
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To: Smokin' Joe
Perhaps this offers hope that humanity will not be wiped out by bird flu.

I imagine some folks are pretty depressed about this.

3 posted on 05/29/2006 1:58:20 PM PDT by ClearCase_guy (Never question Bruce Dickinson!)
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To: ClearCase_guy
I imagine some folks are pretty depressed about this.

Yeah. You're right.

I, for one, was looking forward to the hopeful possibility it would mutate into something that could kill me, my wife, my kids and my grandchildren!

I guess I'll just have to suffer with the unhappy prospects of us all dying of old age.

*sigh*

4 posted on 05/29/2006 2:05:57 PM PDT by Gritty (It’s not that high-tech medicine doesn’t exist, but that it won’t be available – Dr M Osterholm)
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To: Smokin' Joe

Bird flu? Hell, I'm still waiting for SARS...


5 posted on 05/29/2006 2:09:56 PM PDT by xcamel (Press to Test, Release to Detonate)
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To: Smokin' Joe

I hope this is true. I'm a little skeptical of a vaccine developed before the variation becomes communicable between humans because the virus mutates on a monthly basis.

But, let's hope it works and can be made in sufficient quantities.


6 posted on 05/29/2006 2:13:31 PM PDT by Dog Gone
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To: Dog Gone
It isn't just a potential boon to humans, although that is my first area of concern.

If this can be made to stop the disease in birds, that should limit if not stop the problem, except for occasional isolated outbreaks.

Saving poultry flocks from these two diseases (H5N1 and Newcastle) would mean no small economic salvation for the poultry industry as well.

7 posted on 05/29/2006 2:19:56 PM PDT by Smokin' Joe (How often God must weep at humans' folly.)
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To: Dog Gone
Check on Newcastle outbreak in southern California, around 1974. I saw it. The county agricultural agent had vaccine that I personally administered to chickens and ducks. It worked on the asymptomatic fowl. It was termed "bird flu". We were told that it could become communicable in humans. Killed all of our ducks, and all but 4 chickens. But there was a vaccine even then.
8 posted on 05/29/2006 2:20:40 PM PDT by ARealMothersSonForever (Political troglodyte with a partisan axe to grind)
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To: xcamel
SARS did kill 10% of those infected. It wasn't a huge number unless you happened to be one of those infected.

I'm guessing this is way too long for you to read.

Infectious diseases remain the number one killer of humans worldwide. Currently, more than 39 million people live with HIV, and last year about 2.9 million people died of AIDS, bringing the cumulative total of deaths from AIDS to approximately 25 million. Tuberculosis (TB) and malaria also remain major causes of death. In 2003, about 8.8 million people became infected with TB, and the disease killed more than 2 million. Each year, malaria causes more than 1 million deaths and close to 5 billion episodes of clinical illness. In addition, newly emerging infections, diarrheal and other vector-borne diseases, and agents resistant to antibiotics pose a serious and growing public health concern.

Given so many other significant infectious diseases, why does another influenza pandemic merit unique and urgent attention? First, of the more than 1,500 microbes known to cause disease in humans, influenza continues to be the king in terms of overall mortality. Even in a year when only the garden-variety strains circulate, an estimated 1-1.5 million people worldwide die from influenza infections or related complications. In a pandemic lasting 12 to 36 months, the number of cases and deaths would rise dramatically.

Recent clinical, epidemiological, and laboratory evidence suggests that the impact of a pandemic caused by the current H5N1 strain would be similar to that of the 1918-19 pandemic. More than half of the people killed in that pandemic were 18 to 40 years old and largely healthy. If 1918-19 mortality data are extrapolated to the current U.S. population, 1.7 million people could die, half of them between the ages of 18 and 40. Globally, those same estimates yield 180-360 million deaths, more than five times the cumulative number of documented AIDS deaths. In 1918-19, most deaths were caused by a virus-induced response of the victim's immune system -- a cytokine storm -- which led to acute respiratory distress syndrome (ARDS). In other words, in the process of fighting the disease, a person's immune system severely damaged the lungs, resulting in death. Victims of H5N1 have also suffered from cytokine storms, and the world is not much better prepared to treat millions of cases of ARDS today than it was 85 years ago. In the 1957-58 and 1968-69 pandemics, the primary cause of death was secondary bacterial pneumonias that infected lungs weakened by influenza. Although such bacterial infections can often be treated by antibiotics, these drugs would be either unavailable or in short supply for much of the global population during a pandemic.

The arrival of a pandemic influenza would trigger a reaction that would change the world overnight. A vaccine would not be available for a number of months after the pandemic started, and there are very limited stockpiles of antiviral drugs. Plus, only a few privileged areas of the world have access to vaccine-production facilities. Foreign trade and travel would be reduced or even ended in an attempt to stop the virus from entering new countries -- even though such efforts would probably fail given the infectiousness of influenza and the volume of illegal crossings that occur at most borders. It is likely that transportation would also be significantly curtailed domestically, as smaller communities sought to keep the disease contained. The world relies on the speedy distribution of products such as food and replacement parts for equipment. Global, regional, and national economies would come to an abrupt halt -- something that has never happened due to HIV, malaria, or TB despite their dramatic impact on the developing world.

The closest the world has come to this scenario in modern times was the SARS (severe acute respiratory syndrome) crisis of 2003. Over a period of five months, about 8,000 people were infected by a novel human coronavirus. About ten percent of them died. The virus apparently spread to humans when infected animals were sold and slaughtered in unsanitary and crowded markets in China's Guangdong Province. Although the transmission rate of SARS paled in comparison to that of influenza, it demonstrated how quickly such an infectious agent can circle the globe, given the ease and frequency of international travel. Once SARS emerged in rural China, it spread to five countries within 24 hours and to 30 countries on six continents within several months.

The SARS experience teaches a critical lesson about the potential global response to a pandemic influenza. Even with the relatively low number of deaths it caused compared to other infectious diseases, SARS had a powerful negative psychological impact on the populations of many countries. In a recent analysis of the epidemic, the National Academy of Science's Institute of Medicine concluded: "The relatively high case-fatality rate, the identification of super-spreaders, the newness of the disease, the speed of its global spread, and public uncertainty about the ability to control its spread may have contributed to the public's alarm. This alarm, in turn, may have led to the behavior that exacerbated the economic blows to the travel and tourism industries of the countries with the highest number of cases."

SARS provided a taste of the impact a killer influenza pandemic would have on the global economy. Jong-Wha Lee, of Korea University, and Warwick McKibbin, of the Australian National University, estimated the economic impact of the six-month SARS epidemic on the Asia-Pacific region at about $40 billion. In Canada, 438 people were infected and 43 died after an infected person traveled from Hong Kong to Toronto, and the Canadian Tourism Commission estimated that the epidemic cost the nation's economy $419 million. The Ontario health minister estimated that SARS cost the province's health-care system about $763 million, money that was spent, in part, on special SARS clinics and supplies to protect health-care workers. The SARS outbreak also had a substantial impact on the global airline industry. After the disease hit in 2003, flights in the Asia-Pacific area decreased by 45 percent from the year before. During the outbreak, the number of flights between Hong Kong and the United States fell 69 percent. And this impact would pale in comparison to that of a 12- to 36-month worldwide influenza pandemic.

The SARS epidemic also raises questions about how prepared governments are to address a prolonged infectious-disease crisis -- particularly governments that are already unstable. Seton Hall University's Yanzhong Huang concluded that the SARS epidemic created the most severe social or political crisis encountered by China's leadership since the 1989 Tiananmen crackdown. China's problems probably resulted less from SARS' public health impact than from the government's failed effort to allay panic by withholding information about the disease from the Chinese people. The effort backfired. During the crisis, Chinese Premier Wen Jiabao pointed out in a cabinet meeting on the epidemic that "the health and security of the people, overall state of reform, development, and stability, and China's national interest and image are at stake." But Huang believes that "a fatal period of hesitation regarding information-sharing and action spawned anxiety, panic, and rumor-mongering across the country and undermined the government's efforts to create a milder image of itself in the international arena."

Widespread infection and economic collapse can destabilize a government; blame for failing to deal effectively with a pandemic can cripple a government. This holds even more for an influenza pandemic. In the event of a pandemic influenza, the level of panic witnessed during the SARS crisis could spiral out of control as illnesses and deaths continued to mount over months and months. Unfortunately, the public is often indifferent to initial warnings about impending infectious-disease crises -- as with HIV, for example. Indifference becomes fear only after the catastrophe hits, when it is already too late to implement preventive or control measures.


9 posted on 05/29/2006 2:39:23 PM PDT by Dog Gone
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To: Smokin' Joe

I hate to think this way . . . except that there are hoards of evil types working and thinking that way to evil ends . . .

So, let me get this straight . . . they've got a vaccine for the birds and the elite and the rest of us can just contribute our lives to the NWO DEpopulation project?

Aren't they sweet!

/sar


10 posted on 05/29/2006 2:42:56 PM PDT by Quix (PRAY AND WORK WHILE THERE'S DAY! Many very dark nights are looming. Thankfully, God is still God!)
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To: xcamel

Can't even remember what SARS stood for anymore.


11 posted on 05/29/2006 2:54:18 PM PDT by Jille (The truth shall set you free.)
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To: Jille
"Can't even remember what SARS stood for anymore."

Severe Acute Respitory Syndrome
* 883 died worldwide.

12 posted on 05/29/2006 3:29:52 PM PDT by blam
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To: blam

883 people died doing stupid human tricks after drinking today just in the US


13 posted on 05/29/2006 4:06:59 PM PDT by xcamel (Press to Test, Release to Detonate)
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To: Dog Gone

Thanks for the "chicken little" report - I've been hearing the same crap for 40 years - guess what - no pandemic plagues. Just a little of natures pruning.


14 posted on 05/29/2006 4:09:09 PM PDT by xcamel (Press to Test, Release to Detonate)
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To: xcamel

Okay, whatever you say. No pandemics ever again. That's quite a relief.


15 posted on 05/29/2006 5:28:48 PM PDT by Dog Gone
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To: Dog Gone
I'm not saying none/ever - I'm saying that the conditions that led to the 1918-1919 flu pandemic no longer exist in 75% of the civilized world.



16 posted on 05/29/2006 5:39:34 PM PDT by xcamel (Press to Test, Release to Detonate)
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To: sneakers

bump


17 posted on 05/29/2006 7:22:07 PM PDT by sneakers
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