you need to go research Japan's biological weapon it developed --- and used --- on China.
Japan was months away from bombing San Fransico with cholera and plauge (clay bomblets with infected fleas) when we nuked them.
Bred the diseases to be antibiotic resistent, in fact.
Parts of China are still uninhabitable.
Things were very close to total disaster. We don't like to think that, though.
Maybe I'm completely naive about this, but how the hell was Japan going to drop a bomb on San Francisco? Did they have some kind of super-duper-long-range bomber program that I'm not aware of?