The Science Of Sexual Orientation (Mega Barf Alert!)

(CBS) There are few issues as hotly contested — and as poorly understood — as the question of what makes a person gay or straight. It's not only a political, social, and religious question but also a scientific question, one that might someday have an actual, provable answer.

The handful of scientists who work in this under-funded and politically charged field will tell you: That answer is a long way off. But as Lesley Stahl reports, their efforts are already yielding tantalizing clues. One focus of their research is twins.

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The bedrooms of 9-year-old twins Adam and Jared couldn't be more different. Jared's room is decked out with camouflage, airplanes, and military toys, while Adam's room sports a pastel canopy, stuffed animals, and white horses.

When Stahl came for a visit, Jared was eager to show her his G.I. Joe collection. "I have ones that say like Marine and SWAT. And then that's where I keep all the guns for 'em," he explained.

Adam was also proud to show off his toys. "This is one of my dolls. Bratz baby," he said.

Asked if he went to school like that, Adam says, "Uh-huh. I just showed them my nails, and they were like, 'Why did you do that?'"

Adam's behavior is called childhood gender nonconformity, meaning a child whose interests and behaviors are more typical of the opposite sex. Research shows that kids with extreme gender nonconformity usually grow up to be gay.

Danielle, Adam and Jared's mom, says she began to notice this difference in Adam when he was about 18 months old and began asking for a Barbie doll. Jared, meanwhile, was asking for fire trucks.

Not that much has changed. Jared’s favorite game now is Battlefield 2, Special Forces. As for Adam, he says, "It's called Neopets: The Darkest Faerie."

Asked how he would describe himself to a stranger, Jared says, "I'm a kid who likes G.I. Joes and games and TV."

"I would say like a girl," Adam replied to the same question. When asked why he thinks that is, Adam shrugged.

"To me, cases like that really scream out, 'Hey, it's not out there. It's in here.' There's no indication that this mother is prone to raise very feminine boys because his twin is not that way," says Michael Bailey, a psychology professor at Northwestern University and a leading researcher in the field of sexual orientation.

Psychologists used to believe homosexuality was caused by nurture — namely overbearing mothers and distant fathers — but that theory has been disproved. Today, scientists are looking at genes, environment, brain structure and hormones. There is one area of consensus: that homosexuality involves more than just sexual behavior; it’s physiological.

Bailey and his colleagues set up a series of experiments in his lab at Northwestern University. In one study, researcher Gerulf Rieger videotaped gay and straight people sitting in a chair, talking. He then reduced them visually to silent black and white outlined figures and asked volunteers to see if they could tell gay from straight. The idea was to find out if certain stereotypes were real and observable.

Based on physical movement and gestures of the figures, more often than not, the volunteers in the study could tell a difference.

"So, is the conclusion that gay people do in fact move differently?" Stahl asked Rieger.

It's not true 100 percent of the time; it is true on average. The researchers also studied the way gay and straight people talk, and they found differences on average there too.

This research is controversial. Some say it is reinforcing stereotypes. But to Bailey, the stereotypes suggest there's a feminizing of the brain in gay men, and masculinizing in lesbians. Ironically though, when it comes to their sex lives, he says gay and straight men actually have a lot in common.

"Straight men tend to be shallow in terms of focusing on looks. Gay men are shallow, too. Straight men are more interested than straight women in having casual, uncommitted sex. Gay men are like that, too," says Bailey.

"One has the impression that gay men are much more inclined toward casual sex than straight men," Stahl said.

"They're just more successful at it, because the people they're trying to have sex with are also interested in it," Bailey explained.

"But don't you find this interesting that the one big area where gay men are more like straight men is in sex? I mean, that is…both amusing and odd," Stahl said.

"It suggests that whatever causes a man to be gay doesn't make him feminine in every respect. There must be different parts of the brain that can be feminized independently from each other," Bailey replied.

But how and when does this feminizing occur? If the differences were already apparent in childhood, that would point to an early, perhaps even genetic origin — and that's what Bailey and Rieger are testing in a new study using childhood home movies.

In the study, volunteers were asked to rate each child's femininity or masculinity. Stahl took the test and rated two girls highly feminine.

When shown video of a toddler girl running a truck off of a table, Stahl observed, "She's really not girly. Isn't that interesting? She’s not girly."

She also observed differences in two boys, one of whom would grow up to be straight, while the other is now gay.

If you can spot a child's future sexual orientation before the child even knows he or she has one, doesn't that prove it's genetic? Studies have shown that homosexuality runs in families. So genes must be the answer. But then the researchers tell you identical twins can have different sexual orientations.

60 Minutes found identical twins Steve and Greg Lofts in New York. They had the same upbringing, have the same DNA — and yet Greg is gay and Steve is straight.

When people meet the twins and find out one of them is gay, Greg says people have asked if he's sure, and how it can be. "Everyone is curious about that," he says.

There were signs, even when they were little kids. Their mother told Stahl that Steve loved sports and the outdoors while Greg liked helping out in the kitchen. But it wasn't until high school that Steve became convinced Greg was gay.

Asked if he said anything to his brother, Steve says, "I did actually. And I think the way I worded it was something like, 'You know, Greg, if you're gay, it's OK with me. And I'll still love you the same.' And he gave a very philosophical answer. He said something like, 'Well, I love the soul of a person and not the physical being.' And in my mind, I was like, 'Yep, he's gay.'"

"What it proves is it's not completely genetic. They have the same genes," says Bailey.

"That's environment. But that's not the only environment. There's also the environment that happens to us while we’re in the womb. And scientists are realizing that environment is much more important than we ever thought it was," Bailey explained.

A newborn rat pup in the lab of Dr. Marc Breedlove at Michigan State University, may, oddly enough, hold important clues to what happens in the womb.

Dr. Breedlove says he can take a male rat and make it behave like a female for the rest of its life, and vice versa for a female, just by altering the hormones it's exposed to at birth. Because rats are born underdeveloped, that's roughly the same as altering a third-trimester human fetus in the womb. But first, he said, Stahl would need a crash course in rat sex.

Dr. Breedlove explained that male rats, including one he showed Stahl called "Romeo," will mount any rat that comes their way. In the mating process, the female performs something called lordosis, where she lifts her head and rump.

If Romeo goes after a male, Dr. Breedlove says the male will seem profoundly indifferent.

But Breedlove says he can change all that. He gave a female rat a single shot of the male sex hormone testosterone at birth. Now grown up, she will never perform lordosis.

"I wouldn't say that these are gay rats. But I will say that these are genetic male rats who are showing much more feminine behavior," he explained.

"That's exactly the question that we're all wondering. This business of testosterone having such a profound influence. Does that have some relevance to humans?" Breedlove said.

While biologists look at hormones for answers about human sexuality, other scientists are looking for patterns in statistics. And hard as this is to believe, they have found something they call "the older brother effect."

"The more older brothers a man has, the greater that man's chance of being gay," says Bailey.

If this comes as a shock to you, you’re not alone. But it turns out, it’s one of the most solid findings in this field, demonstrated in study after study.

And the numbers are significant: for every older brother a man has, his chances of being gay increase by one third. Older sisters make no difference, and there's no corresponding effect for lesbians. A first-born son has about a 2 percent chance of being gay, and the numbers rise from there. The theory is it happens in the womb.

"Somehow, the mother's body is remembering how many boys she's carried before," says Breedlove. "The favorite hypothesis is that the mother may be making antibodies when she sees a boy the first time, and then affect subsequent boys when she carries them in utero."

"And if you think about it, a woman who's carrying a son for the first time, she is carrying a foreign substance," Breedlove replied. "There are some proteins encoded on his Y chromosome that her body has never seen before and that her immune system would be expected to regard as 'invaders,'" he added.

"One of the things we've only found out lately is that older brothers affect a boy only if the boy is right-handed," Breedlove said. "If the boy is left-handed, if his brain is organized in a left-handed fashion, it doesn't matter how many older brothers he has, his probability of being gay is just like the rest of the population."

You can give yourself a headache trying to apply all the theories to real people. Greg and Steve Lofts both are right-handed, and they do have an older brother, so maybe that's why Greg is gay. But they also have several gay relatives, which suggests it could be in the genes, except where does that leave Steve?

Then there's the question of how something in the womb could affect one twin but not the other. There are many more questions at this point than answers, but the scientists 60 Minutes spoke to are increasingly convinced that genes, hormones, or both — that something is happening to determine sexual orientation before birth. Adam has come up with his own theory.

"I was supposed to be a girl in my mom's stomach. But my mom wished for all boys. So, I turned into a boy," Adam explained.

"Do you think there was anything that you could have done that would have changed Adam?" Stahl asked Adam and Jared's mom Danielle.

"I could have changed Adam on the outside to where he would have showed me the macho boy that I would want as a boy. But that would not change who he is inside. And I think that would have damaged him a lot more," she said.

Stahl asked both boys if they are proud of the way they are, and both boys gave her big nods.

I feel like I'm living in some alternate reality. . . I never said anything about group sex, prison sex, or "circle jerks." Now am I delusional or are you actually misdirecting a reply to me that should go to someone else??

Yes, it is a theory that anti-male antibodies may be responsible for the fraternal birth order effect, but it is not without grounds. In order to conceive in the first place a woman's immune system needs to be locally depressed in the uterus to allow implantation to occur--otherwise her white blood cells can kill the zygote. It's well known that tissues and cells introduced from another person can cause an immune response, which is why blood transfusions require blood type matching and why transplants require allotype matching and immunosuppression.

What a conflicted set of posts - ranging from commiseration and semi-acceptance - to damnation of thought and writer. Is the mis-spelling of your name intentional or do you "profess" to be a professor?

I was hoping to engage some bright minds in dialogue for that is what I believed forums thrived upon.

It seems you have other dedicated goals - that of censure and personal attack.

Your chance remark made me laugh - we are all born with nipples or hadn't you noticed. Just a casual aside for you only.

If you are going to promote the evils of homosexuality, then please do so, with reasoned response and clarity.

Happy St. Patrick's Day Prof !

Actually, it is simply getting tiresome to watch the parade of gay threads; I haven't the slightest interest in their behavior or their concerns.

And I have never said I was a professor, I just like reading other opinions and often find news here quicker than elsewhere.

My online name is just an old joke.

You are indeed correct that I somehow misdirected my reply to another post to you; sorry for that and the resulting confusion, but I am only partly taking any of this seriously as I can believe that we are about to reorder society on the basis of someone's claim that they are somehow different than the rest of us without some proof to establish such fact, especially if we are expected to also apologize for our reluctance.

The gay movement goes beyond simple sexual attraction and hormonal heuristics; it is a spiritual calling to the liberation of the fettered lesser half of the inner zygote in each of us...

ROTFLMAO

The only ones pushing their agenda here is the religious crowd, like DBeers, who I've seen get smashed in other posts by more intelligent characters - so he comes here and takes it out on homosexuals

Oh really?

Yeah.

LOL --well good for you. I dsuspect you may retread troll... Regardless, your eventual zotting will probably please many more than most of the others who came before you...

First of all, your attention is starting to bug me. Leave me alone. Second, if you ignore that request, kindly speak cogently in English. Third, you like to call people trolls. Projection? Finally, are you 12 years old? Have a nice day.

First of all, your attention is starting to bug me.

Try DU -I do not post there and you will be able to advocate the homosexualization of society unfettered there.

The way you're chasing me, I'm starting to think my initial suspicion about you was correct.

Chasing you? LOL -- take a look at who posted this article. No one forces you to post on this topic let alone reply to my comments... A proverbial saying comes to mind: "If you don't like the heat get of of the kitchen" Maybe you should ban yourself from FR if that will make you feel better...

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