Big spending and open borders are the biggest issues I take Republicans to task on. As long as a Presidential candidate or congress refrain from shoving "(Un)intelligent design" down our throats, the creationists will remain moonbats within their own communities, rather than part of a national movement.
To me the War on Terror is the biggest issue and dwarfs all the other issues.
Unfortunately, they often try to inject their moonbat ideas into the public school curriculum, which then leads to lawsuits in Federal court, which in turn makes it a national issue.
The only long-term solution as I see it is to get them to realize what Christians in other realized long ago: evolution is no threat to the Faith.