That's one bad rabbit. I usually settle with garden munchers with a 8 3/8th inch Smith model 48 .22 Mag with a 2 power Burris on it. The only 9 I have right now is a Sig 225.
The .22 mag is really explosive, and I guess that's why it is said to be extremely effectibe for slaughtering cattle with brain shots. I have shot rabbits (to control a large predator problem) through the chest with .22 LR, and was amazed at how tenacious they are. It seemed like I had hit them with a cannon, relative to their size, but they did not stop. That is a rather horrible situation to behold for a person who does not like to inflict suffering on any animal, death perhaps, but not suffering. Squantos may chime in with a similar report, if he feels like being flamed for flights of fantasy, or really miserable shooting.
Hey, I have been told that the .22 Mag. is inherently inaccurate. I have advised a relative to get a Ruger in that cartridge...since he bought a used Western holster with a lot of those rounds still in the loops, and wants something for fun shooting, as well as general farm utility, and defense against dogs and cougars. I suppose it would do "something" against the big 'n nasty...but.....!
I opt for the Holy Hand Grenade of Antioch.