The Jews were expelled from Spain by a decree of King Ferdinand (of and Isabella fame). The inquisition was another matter, entirely.
Yes, and Christ was crucified by Pontius Pilate. The "trial" by the Sanhedrin was another matter, entirely.
Specifically:
"In 1481 the Inquisition started in Spain and ultimately surpassed the medieval Inquisition, in both scope and intensity. Conversos (Secret Jews) and New Christians were targeted because of their close relations to the Jewish community, many of whom were Jews in all but their name. Fear of Jewish influence led Queen Isabella and King Ferdinand to write a petition to the Pope asking permission to start an Inquisition in Spain.
More than 13,000 Conversos were put on trial during the first 12 years of the Spanish Inquisition. Hoping to eliminate ties between the Jewish community and Conversos, the Jews of Spain were expelled in 1492."
Fortunately for me, they also discovered a new place to go that year.
As it is so often, the miracle is in the timing.
Rome was really not to keen on the Spanish Inquisition, because the pope had little control of it.