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An A.L.S. Puzzle on the Soccer Field
NY Times ^ | March 1, 2005 | NICHOLAS BAKALAR

Posted on 03/01/2005 3:54:30 PM PST by neverdem

Why soccer would be a risk for amyotrophic lateral sclerosis is a mystery.

But a new study has found that Italian professional soccer players get the disease at a rate nearly six times as great as the general population.

The study, led by Dr. Adriano Chiò, a professor in the department of neuroscience at the University of Turin, was inspired by the work of an Italian prosecutor, Raffaele Guariniello, who was investigating soccer players' use of illegal drugs.

As part of his inquiry, he ordered a report on the causes of death among 24,000 men who played professional or semiprofessional soccer in Italy from 1960 to 1996.

His finding - that Italian players died of A.L.S. at a rate almost 12 times as great as normal - puzzled researchers, who decided to undertake a much more rigorous study.

A.L.S., often called Lou Gehrig's disease, is an incurable and invariably fatal degenerative disease of the nervous system.

Although there have been many suggestions about the possible risks for the illness, including participation in sports, no clear-cut evidence has been found for any risk factors except age and sex. (A.L.S. tends to strike around age 60, and a vast majority of patients are men.)

The new study, however, found not only an increased risk among these Italian athletes, but also that the risk was dose-related: the longer an athlete played, the greater his risk of contracting A.L.S.

Moreover, the researchers found, the mean age at which the athletes developed the disease was 51, 10 years younger than the general population. The report appears in the March issue of the journal Brain.

Dr. Chiò said he was surprised by the results.

"I can tell you that when I was asked to perform this study, I thought it would be a waste of time," he said. "I didn't believe I would find any significant result. Now I know I was wrong."

He said the study's methodology was sound.

"We are very confident that these results are real and are not due to a statistical effect," Dr. Chiò said.

But he cautioned that the meaning of the findings was not clear, that A.L.S. is a very rare disease and that the study's results in no way suggested that anyone should stop playing soccer.

"I think this is a very good study," said Dr. Ruth Ottman, a professor of epidemiology at Columbia University. "The methodology seems quite rigorous, and the dose-response relationship supports the validity of the results."

The study's subjects included all native Italian male professional soccer players who were on a team roster from 1970 to 2002 and who had played in at least one official match. The total came to more than 7,000 men.

Eighteen cases of amyotrophic lateral sclerosis were identified. The researchers interviewed all living players who had A.L.S., as well as the doctors and relatives of players who had died from the disease, and compiled detailed medical and personal histories of the patients' activities and health before, during and after their time as active athletes.

The researchers also gathered family histories, paying particular attention to neuromuscular disorders. One form of A.L.S. is inherited, but no affected player had the disease in his family.

Dr. Chiò and his colleagues suggest several explanations, none of them with certainty. Perhaps, they say, A.L.S. is related to heavy physical exercise, and therefore not related particularly to soccer.

Or maybe trauma, particularly the head trauma involved in heading the ball or repeated traumas involving the legs, is a factor. Illegal or legal therapeutic drugs may also be involved, and it is possible that environmental toxins like fertilizers or herbicides used on soccer fields play a role.

The authors concede, however, that each of these hypotheses has weaknesses, and the puzzle endures.


TOPICS: Culture/Society; News/Current Events
KEYWORDS: als; health; italy; lougehrigsdisease; medicine; soccer; sports
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To: AGreatPer

My first inclination is to look at the pesticides and herbicides used on the fields.


41 posted on 03/02/2005 5:26:14 AM PST by AppyPappy (If You're Not A Part Of The Solution, There's Good Money To Be Made In Prolonging The Problem.)
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To: neverdem
I had an uncle succumb to this, 4 months after diagnosis, and wham! gone.

For anecdotal reasons, he was a fireman.

42 posted on 03/02/2005 5:26:47 AM PST by Maigrey ("... I will stand in front of the box to put my heart in it." - Mohammed from Iraq the Blog)
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To: MonaMars
"potential links btwn. lyme disease and ALS."

Even tho it was ruled out by the doctors, my mother in law always felt like Lyme disease was somehow related to her ALS. In the reading I've done, the docs seem to pooh pooh the idea of there being a connection.

43 posted on 03/02/2005 5:27:02 AM PST by sweet_diane ("Will I dance for you Jesus? Or in awe of You be still? I can only imagine..I can only imagine.")
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To: Maigrey
sorry about your uncle, sure was quick for him.

My MIL had about 2.5 years from diagnosis to death. She didn't play soccer but she was one heck of a bowler! Very involved in leagues and competitions, spent several years working the snack bar at the bowling alley. It was while bowling that she noticed her strenght going and began having muscle twitching.

44 posted on 03/02/2005 5:31:16 AM PST by sweet_diane ("Will I dance for you Jesus? Or in awe of You be still? I can only imagine..I can only imagine.")
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To: sweet_diane

Thanks; I had not. Interesting to see if other sports played on natural turf have similar instances of ALS, taking into account US or EU locales.


45 posted on 03/02/2005 6:23:48 AM PST by the lone haranguer (Sola Scriptura, Sola Fide, Sola Gratia)
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To: AGreatPer
No, I enjoy the game, and play routinely. I don't compete, and enjoy running, and kicking around without the killer instinct of MUST WIN IF IT KILLS YOU! That can be saved to the young, the fools, and the professionals. Soccer is a hobby to me.

AS a matter of fact, I play a lot of sports; non with the drive to win if it kills me. For example, I play volley ball, and would never attempt to save a powerful spike. I play basket ball, with no wish to defend the basket against a 250 lbs 6 feet five guy running at & trough me. There is a difference between playing for enjoyment of the game or playing for money. I like the challenge, and the competition, but to a point that is not to risky for my well being. You may call that I stink at these games, I would rather call it a middle age wisdom.

46 posted on 03/02/2005 7:32:10 AM PST by conservlib
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To: thoughtomator

read post 46


47 posted on 03/02/2005 7:33:19 AM PST by conservlib
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To: Maigrey
For anecdotal reasons, he was a fireman.

FWIW, so is my friend.

48 posted on 03/02/2005 8:04:09 AM PST by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
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To: conservlib
"I don't compete"

Everyone to their own feelings.

No matter what game, I personally try to win them all. If I do, great. If I don't, I know I tried.

49 posted on 03/02/2005 8:32:27 AM PST by AGreatPer
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To: AppyPappy
"My first inclination is to look at the pesticides and herbicides used on the fields."

That could well be true over the years. I used to smell some strange stuff over the years. However, modern methods have eleminated or greatly reduced that possibility.

50 posted on 03/02/2005 8:36:59 AM PST by AGreatPer
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To: syriacus
Drugs are used by another group that performs strenuous physical activity -- Rock musicians. I wonder what the rate of ALS is among them.

Well, what's that going on with Ozzie Ozborne?

51 posted on 03/02/2005 9:58:22 AM PST by WL-law
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To: conservlib

Don't blame the attitude, but fielding a soccer ball with one's head or chest (unless it's a hard line drive right at you) isn't really an equivalent of those extreme situations.


52 posted on 03/02/2005 2:32:34 PM PST by thoughtomator (Unafraid to be unpopular)
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To: AGreatPer
Now 65, I am getting a touch of it. Leads me to believe the headers did have something to do with it.

Have you actually been diagnosed as having it?

53 posted on 03/02/2005 4:48:44 PM PST by Tolerance Sucks Rocks (Deport 'em all; let fox sort 'em out!)
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To: Tolerance Sucks Rocks
"Have you actually been diagnosed as having it?"

No, thankfully. However, I have seen enough of it to tell early, early symptons.

I think its all in the genes.

54 posted on 03/02/2005 6:44:20 PM PST by AGreatPer
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To: neverdem

Might be interesting to run a study of college and professional football players to see if the same problems turn up there.


55 posted on 03/02/2005 6:48:47 PM PST by Captain Peter Blood
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To: AGreatPer
However, I have seen enough of it to tell early, early symptons.

I can still hope that you're merely being hit by the old age truck. Hopefully, your symptoms will turn out to be because of something much more benign.

56 posted on 03/03/2005 2:55:37 PM PST by Tolerance Sucks Rocks (Deport 'em all; let fox sort 'em out!)
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