Belichick said himself the Pats will be using an entirely different game plan.
Absolutely, they played the Colts using only 2 D-linemen at times. How do you stop big backs like Bettis and (to a lesser degree) Staley with 2 D-linemen?
Which really goes without saying for Belichick, he completely overhauls the game plan every week, doesn't believe in giving any opponent a chance to truly prepare.