I have always wondered how much more scientific, medical and technological information the world would now posses if it had not been for the Alexandria Fire.
Without Question the Fire was one of the World's greatest tragedies.
Interesting conjecture, what did survive was enough to develop the calculas (at least integral calculas) but the Arabs who translated it did not understand what they had. It took until the enlightenment and Issac Newton to realize and "rediscover" it. But I am astonisned that othes before him did not realize from the proofs of Archimedes what was already done.