This is an awful pick. Ryan could never be more effective than where he is now. Romney takes a true conservative out of a position of power and sends him to foreign funerals for the next four years. Once again the conservatives get screwed!
That is, unless the RINOs join the democrats in the eminent pile on effectively destroying the guy, as they typically do.
That was my first thought, but Ryan could be extremely effective, riding herd on the Republicans in Congress, because he KNOWS them, personally. I think Paul Ryan will be a great asset in the office of the Vice-Presidency.