There was an attempt a few years back to hijack a FED-EX plane and fly it into the HQ building. A crazy employee, armed with a spear gun. The pilots rolled the plane on its back, and generally used the perp as a paddle ball for about 15 minutes. By then he was stunned enough for the co-pilot to take him out single-handed.
The only way that the terrorists took over the four planes on 9-11 was because the crews allowed it to happen. The pilots figured that cooperation was safer than resistance because it had been previously. No more.